10 AGO 2019 · In the PreciAb™ platform, key steps of antibody development are described as follow,
Antibody structure construction through combining structure- and homology-based modeling methods
Structure optimization by dynamics simulation, rotamer library, loop modeling, and etc.
Complementarity-determining region (CDR) identification on the basis of tertiary structure of the antibody
Antibody-antigen complex modeling and interaction analysis
Paratope and epitope identification and key residues analysis
Computer-aided antibody affinity maturation and function modification
Global analysis and optimization of antibody biophysical properties (thermodynamic stability, aggregation propensity, immunogenicity)
https://www.creative-biolabs.com/preciab/preciab-platform.htm
10 AGO 2019 · Computer science and technology has made tremendous progress in the past decade, and it has influenced every aspect of our life. Since the late 1990s, computational biology has become an important part of emerging technologies in the field of biology. Benefit from the advancement in the development of computer hardware, such as the advent of supercomputer, and the programming language for computational biology, scientists are able to achieve structural information with more details, which is not only necessary to understand the various function and mechanism of biological molecules, but also, more importantly, the key to the design of candidate molecules with new or improved functions. https://www.creative-biolabs.com/preciab/preciab-platform.htm
10 AGO 2019 · A variety of strategies are utilized in camelid antibody structure determination, such as nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography, Cryo-electron microscopy density maps, and so on. The first class antibody structure determination services pertain available for customers to promote antibody design and drug discovery progress. https://www.creative-biolabs.com/preciab/antibody-structure-determination.htm
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