Most engineered human cells created for studying disease
30 gen 2025 ·
9 min. 29 sec.
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Descrizione
Researchers have engineered and analysed many random versions of human genomes in cell lines to ultimately understand the role of structural changes in disease. The most complex engineering of human...
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Researchers have engineered and analysed many random versions of human genomes in cell lines to ultimately understand the role of structural changes in disease.
The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.
Researchers from the Wellcome Sanger Institute, Imperial College London, Harvard University in the US and their collaborators used CRISPR prime editing to create multiple versions of human genomes in cell lines, each with different structural changes. Using genome sequencing, they were able to analyse the genetic effects of these structural variations on cell survival.
The research, published today (30 January) in the journal Science, shows that as long as essential genes remain intact, our genomes can tolerate significant structural changes, including large deletions of the genetic code. The work opens the door to studying and predicting the role of structural variation in disease.
mostra meno
The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.
Researchers from the Wellcome Sanger Institute, Imperial College London, Harvard University in the US and their collaborators used CRISPR prime editing to create multiple versions of human genomes in cell lines, each with different structural changes. Using genome sequencing, they were able to analyse the genetic effects of these structural variations on cell survival.
The research, published today (30 January) in the journal Science, shows that as long as essential genes remain intact, our genomes can tolerate significant structural changes, including large deletions of the genetic code. The work opens the door to studying and predicting the role of structural variation in disease.
Informazioni
| Autore | Wellcome Sanger Institute |
| Organizzazione | Wellcome Sanger Institute |
| Sito | - |
| Tag |
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