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Latest News and Research
Latest News and Research
25 SET 2024 · https://www.sanger.ac.uk/external_person/lotfollahi-mo/ recently joined the Wellcome Sanger Institute as a new Group Leader in the Cellular Genetics programme. Mo works with wet lab scientists and bioinformaticians to develop generative artificial intelligence (AI) models for predicting cellular responses. In this blog, we spoke to Mo about his research and vision for the future of AI in biology.
23 SET 2024 · Scientists have conducted the largest and most diverse study to date on how recessive genetic changes contribute to developmental disorders. They found that most undiagnosed cases that are due to recessive causes are linked to genes we already know about.
Researchers from the Wellcome Sanger Institute and their collaborators at GeneDx analysed genetic data from nearly 30,000 families affected by developmental disorders – six times more families with greater diversity in ancestral backgrounds compared to previous work.
While discovering several genes that were previously not linked to these conditions, researchers found that known genes explain over 80 per cent of cases caused by recessive genetic variants. This is a significant increase from previous estimates. The study also revealed the contribution of recessive genetic variants to developmental disorders varies significantly across the ethnic groups studied.
The findings, published today in the journal Nature Genetics, shed new light on the genetic basis of developmental disorders, and highlight the importance of considering a person's genetic background in diagnosis and research.
20 SET 2024 · Sanger scientists join international collaborators to generate reference genomes for European species.
The European Reference Genome Atlas (ERGA) Pilot Project has brought together collaborators from 33 different European countries to produce high-quality reference genomes for 98 European species.
Announcing the success of its pilot project in https://www.nature.com/articles/s44185-024-00054-6, this continental effort sets the stage for a new inclusive and equitable model for biodiversity genomics.
Of the 98 reference genomes, the Wellcome Sanger Institute was involved in producing 38 pilot study genomes, assembled 14 of these genomes and curated 27.
18 SET 2024 · Scientists have pinpointed thousands of genetic changes in a gene that may increase a person’s risk of developing breast and ovarian cancer, paving the way for better risk assessment and more personalised care.
Researchers from the Wellcome Sanger Institute and their collaborators focused on the ‘cancer protection’ gene RAD51C, known to increase ovarian cancer risk six-fold and risk of aggressive subtypes of breast cancer four-fold1. They found over 3,000 harmful genetic changes that could potentially disrupt its function and increase cancer risk. These findings were confirmed by analysing data from large-scale health databases.
13 SET 2024 · Tapping out the DNA code of the Deathwatch Beetle gives hope to future conservation research into battling this wood-munching marauder.
The tapping sound of the adult Deathwatch Beetle, Xestobium rufovillosum, a wood-boring insect, was traditionally meant to be bad luck, heralding tragedy in a household. Often heard in the quiet of the night, it was thought to be a countdown to death. Ironically, the ominous sound of the tapping adult beetle is actually a beetle duet between male and female adult beetles who tap to find mates in order to carry on the Deathwatch Beetle line.Out of the wood and into the lab, researchers from the Wellcome Sanger Institute have sequenced the genome of the Deathwatch Beetle for the first time.
Armed with the genome sequence of the Deathwatch Beetle, researchers at the https://www.biology.ox.ac.uk/people/peter-holland https://www.nmrn.org.uk/news/researching-deathwatch-beetles-aboard-hms-victory and the https://www.nmrn.org.uk/news/researching-deathwatch-beetles-aboard-hms-victory have joined forces to further the study of the Deathwatch Beetle. Their aim is to assist with ongoing conservation efforts, better understand the beetle’s behaviour, biology and preserve the historic British warship https://www.nmrn.org.uk/visit-us/portsmouth-historic-dockyard/hms-victory.
10 SET 2024 · A common diabetes medication, metformin, slows the growth of precancerous cells in the oesophagus while some metabolic conditions accelerate it, suggests a new study.
Researchers from the Wellcome Sanger Institute discovered that metformin reduced the growth of potentially cancerous cells both in mice and laboratory experiments. The team also found that metabolic conditions such as diabetes and obesity could enhance the growth advantage of these altered cells in human samples.
The findings, recently published in Nature Genetics, highlight the potential role of metformin and overall metabolic health in managing squamous oesophageal cancer risk. Researchers suggest the drug may be beneficial beyond its role in diabetes, though more research is needed.
6 SET 2024 · Did you know that your gut bugs may affect your cancer risk? Dr Ashray Gunjur, Clinical Research Training Fellow at the Wellcome Sanger Institute, is exploring how clinicians can use the biology of the gut microbiome to personalise cancer treatment.
Over three million people in the UK live with cancer, and this is set to rise to 3.5 million by 20251. The past decade saw an increase in cancer patients undergoing immunotherapy, which activates the immune system to fight cancer. Unlike chemotherapy and radiotherapy, immunotherapy specifically targets cancer cells and often minimises collateral damage to healthy cells. However, immunotherapy can be expensive, slower and less effective. It can also trigger negative side effects, including autoimmunity.
But immunotherapy research may have hit a turning point. Scientists have discovered a link between the gut microbiome – the complex community of microorganisms living along the digestive tract – and a person’s response to immunotherapy. https://www.sanger.ac.uk/person/gunjur-ashray/, a Clinical Research Training Fellow at the Wellcome Sanger Institute, investigates whether microbiome-based treatments can increase the effectiveness of immunotherapy for various cancers. I recently met with Ashray to learn about his valuable research, hospital work, and vision for the future of personalised cancer treatments.
Esplicito
6 SET 2024 · In the largest genomic analysis of UK infant microbiomes to date, researchers have uncovered a type of bacterium that helps digest breast milk and protects a baby's gut from pathogens.
Newborn babies have one of three pioneer bacteria in their gut shortly after birth, one of which could be used to develop new personalised infant therapeutic probiotics, researchers show.
This research, https://www.nature.com/articles/s41564-024-01804-9 found that one of these beneficial bacterial pioneers was genetically adapted to make full use of the nutrients in breast milk, suggesting that it is the most suited to thrive in a baby’s microbiome. The team uncovered that this bacterium can also block pathogens from colonising the babies’ gut, highlighting its significant potential as a natural probiotic.
30 AGO 2024 · New method provides high-resolution surveillance data about multiple common antibiotic-resistant bacteria at once and could help prevent the spread of infections
Researchers have developed a new genomic technique that can track the spread of multiple superbugs in a hospital simultaneously, possibly helping to prevent and manage common hospital infections quicker and more effectively than ever before.
The proof-of-concept study, from the Wellcome Sanger Institute, the University of Oslo, Fondazione IRCCS Policlinico San Matteo in Italy, and collaborators, details a new deep sequencing approach that captures all the common infectious bacteria in a hospital at once. Current methods culture and sequence all pathogens separately which takes longer and requires more work.
28 AGO 2024 · The most comprehensive map of the human endometrium, the inner lining of the uterus, has been created, uncovering diverse cell types and detailing the dynamic changes these go through during the menstrual cycle.
The inner lining of the uterus has been mapped during multiple phases of the menstrual cycle, starting to shed new light on the cells and processes involved and their potential role in conditions such as endometriosis.
Encompassing the widest range of menstrual cycle phases ever mapped, the atlas reveals new insights into endometrium functioning, informing women’s health research. Built by researchers from the Wellcome Sanger Institute, the Nuffield Department of Women’s and Reproductive Health at the University of Oxford, and collaborators, it could help study, understand, and possibly treat conditions such as endometriosis in the future.
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Informazioni
Autore | Wellcome Sanger Institute |
Organizzazione | Wellcome Sanger Institute |
Categorie | Scienze biologiche , Medicina , Natura |
Sito | www.sanger.ac.uk |
communications@sanger.ac.uk |
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