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17 MAG 2025 · A child’s genetic ancestry and their parents’ smoking habits are correlated with the rate and type of new genetic variants that occur in their genome, offering insights into a key biological process that affects genetic disease and human evolution.
Ancestry and lifestyle choices of parents may affect the rate and type of new genetic changes that arise in their children, new research has found.
Published in Nature Communications (15 May), researchers from the Wellcome Sanger Institute, the University of Cambridge and their collaborators analysed whole-genome sequence data from 10,000 parent-child ‘trios’. They studied the influence of ancestry, common genetic variants and environmental factors on the rates and types of de novo mutations (DNMs) – genetic changes that arise in the egg or sperm and are passed down to offspring.
8 MAG 2025 · Research uncovers insights into how particular cancer cells develop and spread throughout the lung.
The ‘cell of origin’ of the second most common lung cancer and the way that it becomes dominant in the lung have been discovered, in a new study in mice and humans from researchers at the Wellcome Sanger Institute, UCL, and the University of Cambridge.
The study, https://www.science.org/doi/10.1126/science.ads9145, revealed that a population of basal cells found in the windpipe outcompete other cell types and become dominant, eventually invading and occupying large areas of the lung.
6 MAG 2025 · In this seventh part of https://www.sanger.ac.uk/innovation/case-studies/ we spoke to Dr Trevor Lawley, Senior Group Leader at the Wellcome Sanger Institute who works in the Parasites and Microbes Programme. Trevor’s is the story of turning basic, fundamental research into innovative science with potential to treat a broad range of human diseases.
Innovation takes many forms – from a tweak that improves technology, all the way to the development of new medicines. Translating science is about applying research, moving it beyond the lab, or closing gaps in technologies so that it can be used to improve our lives. Trevor spoke to us about how he spotted those opportunities and co-founded the clinical company Microbiotica, how he’s building global collaborations with the International Fellows Scheme at Sanger and how the gut microbiomes of babies can give us insight into longer, healthier lives.
1 MAG 2025 · A previously unidentified type of mosquito has been found along the coast of Kenya and Tanzania, with potential implications for malaria surveillance and control.
This newly discovered mosquito, provisionally named the Pwani molecular form, belongs to the Anopheles gambiae complex — a group that includes some of the world’s most important malaria vectors.
This discovery, published (16 April) in https://onlinelibrary.wiley.com/doi/10.1111/mec.17762, was the result of a collaboration between the Wellcome Sanger Institute, the University of Glasgow, and the Ifakara Health Institute in Tanzania. The team’s work reveals the presence of a genetically divergent mosquito that could have profound implications for malaria vector surveillance and insecticide-based control strategies in the region.
29 APR 2025 · We explore how the Barcoding for Beginners programme and BIOSCAN project are using genetic tools to investigate insect diversity across the UK.
24 APR 2025 · New research has found a potential microbial culprit behind the alarming rise in early-onset colorectal cancer.
Exposure to colibactin, a toxin produced by certain strains of the bacterium, Escherichia coli, in early childhood may increase the risk of developing colorectal cancer before the age of 50, new research suggests.
Researchers from the Wellcome Sanger Institute, University of California San Diego and their collaborators analysed 981 colorectal cancer genomes from patients with both early- and late-onset cancer across 11 countries with varying colorectal cancer risk levels.
The new study,https://www.nature.com/articles/s41586-025-09025-8, reports that exposure to colibactin in early childhood imprints a distinct pattern of change, known as the “mutational signature”, on the DNA of colon cells — one that may increase the risk of developing colorectal cancer before the age of 50.
17 APR 2025 · Researchers have explored the evolution of the genetic change that causes chronic myeloid leukaemia and show its ability to drive the disease.
A new study has unveiled when chronic myeloid leukaemia, a type of cancer that affects the blood and bone marrow, arises in life and how fast it grows. Researchers reveal explosive growth rates of cancerous cells years before diagnosis and variation in these rates of growth between patients. Such rapid growth rates had previously not been observed in most other cancers.
Researchers from the Wellcome Sanger Institute and their collaborators used whole genome sequencing to study when BCR::ABL1 – an abnormal fusion of the different genes called BCR and ABL1, which is known to cause chronic myeloid leukaemia. The team investigated when BCR::ABL1 first arises in a blood cell and how quickly these cells with this genetic change then multiply and expand to lead to a diagnosis of a type of leukaemia. The research, published today (9 April) in Nature, contributes to the scientific understanding of how strong this abnormal fusion gene is in its ability to drive cancer.
16 APR 2025 · A major new initiative, launched today (15 April), will map how gene activity shapes the immune system, and could help identify new therapeutic targets for conditions such as Inflammatory Bowel Disease (IBD).
Scientists at the Wellcome Sanger Institute, in collaboration with Pacific Biosciences (PacBio), will use advanced long-read sequencing technology to profile gene expression at single-cell resolution. By applying this technology to nearly 1,500 blood and gut tissue samples from three major ongoing studies, researchers will be able to capture not only the extent to which genes are expressed but also which versions, known as isoforms, of each gene are used.
This approach will provide high-resolution maps of RNA expression and splicing across different cell types, tissues, and individuals. These insights could prove critical to gaining a complete understanding of human health conditions and reveal why some treatments work better for certain people.
9 APR 2025 · Research into transcription factors deepen understanding of the ‘language’ of the genome, offering insights into human development.
New research has uncovered more about the complexity of human gene regulation by identifying certain sequences of proteins called transcription factors that bind to DNA and regulate the expression of human genes.
Published today 9 April) in Nature, researchers from the Wellcome Sanger Institute, the University of Cambridge and their collaborators explored how DNA-guided transcription factors interact with each other. This research adds to the groundwork of understanding the complex language of the gene regulatory code, and how DNA sequence patterns located close to our genes influence human development and disease risk.
7 APR 2025 · In 2025 we welcome a new cohort of International Fellows at the Wellcome Sanger Institute. Six established researchers in Institutes from Low and Middle Income Countries will be joining us for three years to advance their own science in the Sanger Institute environment and help us design and deliver our scientific strategy.
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Informazioni
| Autore | Wellcome Sanger Institute |
| Organizzazione | Wellcome Sanger Institute |
| Categorie | Scienze biologiche , Medicina , Natura |
| Sito | www.sanger.ac.uk |
| communications@sanger.ac.uk |
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