Genesis 4:25
And Adam knew his wife again; and she bare a son, and called his name Seth: For God, said she, hath appointed me another seed instead of Abel, whom Cain slew.

After dealing with Cain’s line in the beginnings of corruption of violence, Moses goes back some years to the birth of “Seth;” the Holy Spirit will single out “Seth,” because he was in the lineage of Christ; the name “Seth” means “appointed substitute”.

When “Cain” was born, Eve said, “I have gotten a man from the LORD,” indicating that she believed in the Covenant of Genesis 3:15.

Now she uses the term “God,” in effect stating that she has lost faith in the Covenant.

As stated, this “seed” would be the one through whom Christ would come, but because of faithlessness, Eve did not know or believe this.

Genesis 4:26
And to Seth, to him also there was born a son; and he called his name Enos: then began men to call upon the name of the LORD.

The name “Enos” means “sickly, mortal, decaying man;” the awful results of the Fall are now beginning to sink in.

This probably refers to contempt; quite possibly the family of Cain, knowing that Seth had now taken the place of Abel, as it regards the “firstborn” or “appointed one,” contemptuously refers to them as the “God people,” or the “Lord people”.

Apparently this was the beginning of men calling upon the name of the Lord.