In this animated adventure expanded from the video game, M. Bison is a megalomaniacal warlord from Thailand with dreams of world domination. Bison runs a super-secret organization of drug smugglers, weapons runners, and an international terror and crime syndicate called "Shadowlaw". Fueling Shadowlaw is a massive drug-running operation and a diabolical plan to become the most military force in the world through the use of ultra-powerful street fighters. Bison has his tech team devise a squad of cyborgs to do reconnaissance to find the best fighters in the world to recruit into his organization as part of a super army better than any individual nation's.

Because the Japanese Shotokan karate master named Ryu has bested Sagat in the Street Fighter Tournament, it marks him as perhaps the world's best, and someone from which Bison can build an army of super-street fighters. Ryu's best friend from San Francisco, Ken Masters, another street fighter who studied the same master (making him the closest fighter to being Ryu's equal) is kidnapped by Bison for brainwashing experiments to convert street fighters to his political assassins, starting with his effort to try to take down the world-wandering Ryu. Vengeful Chun Li and her colleagues at Interpol are trying to take down the operation, as does US Air Force Captain Guile, who is out to take down Bison for killing a friend.