Jennifer Joyce Kesse, born on May 20, 1981, is an American woman from Orlando, Florida, who has been missing since January 23, 2006. Shortly after her disappearance, Kesse's vehicle was found parked approximately one mile from her residence. Security footage captured an individual parking Kesse's car and departing the scene; however, the individual could not be identified due to the poor quality of the video and the lack of any notable distinguishing features. The case garnered significant attention from both local and national media.

As of 2024, despite new leads and extensive searches, no arrests have been made, and Kesse's location remains unknown.

Kesse graduated from Vivian Gaither High School in Tampa, Florida, and went on to attend the University of Central Florida in Orlando, where she earned a degree in finance in 2003. At the time of her disappearance, she was employed as a finance manager at Central Florida Investments Timeshare Company in Ocoee and had recently purchased a condominium in Orlando. The weekend prior to her disappearance, Kesse vacationed with her boyfriend in Saint Croix, U.S. Virgin Islands.