ADEPT antibody is regarded as an “indirect targeting method” that involves two steps. Firstly, a non-toxic antibody–enzyme fusion protein is applied to the tumor matrix and binds to the tumor cells via tumor-specific antigen recognized by the antibody. Upon binding, an inert small-molecule prodrug is then given. The prodrug is the substrate for the enzyme portion of the antibody–enzyme fusion that is anchored to the tumor surface. Once the prodrug reaches the enzyme, an active cytotoxic agent is produced by the enzyme and cause cancer cell death. https://www.creative-biolabs.com/adc/toxic-enzymes-adept.htm